Source: UAB News / GoodRx (March 2026)
As these drugs have become mainstream, the focus has shifted to the long-term physical changes that occur during rapid weight loss.
- Sarcopenia (Muscle Loss): A significant concern in 2026 is that up to 40% of weight lost on GLP-1s can be lean muscle mass rather than fat. This can lead to weakness and a lower metabolic rate, making weight regain more likely if the drug is stopped.
- Cosmetic Changes: "Ozempic Face" (hollowed, sagging skin) and temporary hair...